StudentAidUnit 7: Structural and Computational Biology — Mcqs
11th Class Biology · Unit 7: Structural and Computational Biology
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1.Generally, the function of a protein depends on its:
2.The protein domains are:
3.The first step in x-ray crystallography experiment is:
4.What is primary role of computational biology?
5.Which computational approach is used to predict protein structure based on amino acid sequence?
Applications of Structural Biology
6.What is the primary focus of structural biology?
7.Which technique is used to determine the 3D-structure of proteins?
8.The active site of enzyme is important in designing a drug, because:
9.How did structural biology contribute to COVID-19 research?
10.The structural studies of enzyme HIV-L reverse transcriptase have identified its:
11.The place on a disease-causing molecule where a drug can work are called:
12.Protein misfolding is associated with which of the following diseases?
X-ray Crystallography
13.The first step in x-ray crystallography is:
14.In x-ray diffraction technique, the diffraction pattern is used to:
Computational Biology
15.The field that uses computational tools to analyze biological data is:
16.Which of the following is not the area in computational biology?
17.Sequencing, assembling and analyzing the function and structure of genomes is studied in:
18.Mapping the entire set of proteins produced by an organism and to understand their interactions and roles in cellular process, is achieved in:
19.Which field of biology helps in identifying genetic variations associated with diseases?
20."https://www.ncbi.nlm.nih.gov/nuccor e/" is a link for:
21.Which database stores 3D structures of macromolecules?
22.The database of nucleotide sequences and supporting bibliographic annotations is:
23.A genome browser providing information on genome sequences, gene models and comparative genomics for various species is:
24.Which one of the following is a sequence alignment tool that compares a query sequence to a database of sequences?
- a BLAST
- b FASTA
- c EMBL
- d PDB
25.A researcher wants to search protein and nucleotide databases to identify sequence homology, which one is most appropriate to study?
Sequence Homology
26.What is sequence homology?
27.Orthologs are:
- a Genes in same species
- b Human histone H1.1 and H1.2
- c Sequences in different species
- d Arise from same ancestral gene
28.Human histone H1.1 and Human histone H1.2 are:
29.Human histone H1.1 and Chimpanzee histone H1.1 are:
30.How does structural homology helps in drug designing?
31.If two proteins have structural homology what can be inferred:
32.The tool used for sequence alignment in bioinformatics:
33.Which bioinformatics tools acts like a 'Google Search' for DNA sequences?
34.The biologists compare protein structures to unknown genes?
35.Identify the missing step in X-ray crystallography:
1. Crystallize protein → 2. X-ray diffraction 3 → 2 → 4. 3D model
36.A researcher is studying a newly discovered protein, linked to a disease. The protein's sequence shows no match in BLAST, the next possible step is:
37.Orthology differ from paralogs in:
38.The limitation of homology modeling is: